eComment. Levosimendan in adult patients undergoing cardiac surgery.
نویسنده
چکیده
[1] Toller W, Algotsson L, Guarracino F, Hormann C, Knotzer J, Lehmann A et al. Perioperative use of levosimendan: Best practice in operative settings. J Cardiothorac Vasc Anesth 2013;27:361–366. [2] Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ. Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with severe heart failure. J Clin Pharmacol 2002;42:43–51. [3] Angadi U, Westrope C, Chowdhry MF. Is levosimendan effective in paediatric heart failure and post-cardiac surgeries? Interact CardioVasc Thorac Surg 2013;17:710–15. [4] Yavuz S, Eris C, Sezen M, Goncu T, Ata Y, Turk T. Preoperative use of levosimendan in patients with severe left ventricular dysfunction undergoing coronary artery bypass grafting. Interact CardioVasc Thorac Surg 2009;8(Suppl 1):S1. [5] Leppikangas H, Jarvela K, Sisto T, Maaranen P, Virtanen M, Lehto P et al. Preoperative levosimendan infusion in combined aortic valve and coronary bypass surgery. Br J Anaesth 2011;106:298–304.
منابع مشابه
Effect of levosimendan on prognosis in adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials
BACKGROUND Small trials suggest that levosimendan is associated with a favorable outcome in patients undergoing cardiac surgery. However, recently published larger-scale trials did not provide evidence for a similar benefit from levosimendan. We performed a meta-analysis to assess the survival benefits of levosimendan in patients undergoing cardiac surgery and to investigate its effects in subg...
متن کاملSingle-center experience with levosimendan in children undergoing cardiac surgery and in children with decompensated heart failure
BACKGROUND Levosimendan has pharmacologic and hemodynamic advantages over conventional intravenous inotropic agents. It has been used mainly as a rescue drug in the pediatric intensive care unit or in the operating room. We present the largest single-center experience of levosimendan in children. METHODS Retrospective analysis of all children who received levosimendan infusions between July 5...
متن کاملLevosimendan in Pediatric Cardiac Surgery: An Evidence Based Review
Levosimendan (LS) is a calcium sensitizing agent with inotropic properties. It has been shown to improve cardiac function, haemodynamic performance and survival in adult with heart failure. Intraoperative administration of levosimendan during adult cardiac surgery have been shown to be beneficial. This new rescue drug also has some beneficial effects in pediatric cardiac surgery. Over the last ...
متن کاملEffect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis.
OBJECTIVE Left ventricular systolic dysfunction is associated with increased morbidity and mortality in patients undergoing cardiac surgery. The authors performed a meta-analysis investigating the effects of levosimendan in cardiac surgery patients with and without preoperative systolic dysfunction. DESIGN Meta-analysis of randomized controlled trials. SETTING Hospital. PARTICIPANTS The 1...
متن کاملImpact of prophylactic administration of Levosimendan on short-term and long-term outcome in high-risk patients with severely reduced left-ventricular ejection fraction undergoing cardiac surgery – a retrospective analysis
BACKGROUND Patients with severely reduced left-ventricular ejection fraction carry a high risk of morbidity and mortality after cardiac surgery. Levosimendan can be used prophylactically in these patients having shown positive effects on short-term outcome. However, effects on long-term outcome and patient subgroups benefiting the most are unknown. We aim to address these topics with real-life ...
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عنوان ژورنال:
- Interactive cardiovascular and thoracic surgery
دوره 17 4 شماره
صفحات -
تاریخ انتشار 2013